Ion channelopathy and hyperphosphorylation contributing to cardiac arrhythmias1

Basic Mechanisms of Cardiac Arrhythmias1

Diabetic Dead-in-Bed Syndrome: A Possible Link to a Cardiac Ion Channelopathy

Sudden unexpected nocturnal death among patients with diabetes occurs approximately ten times more commonly than in the general population. Malignant ventricular arrhythmia due to Brugada syndrome has been postulated as a cause, since a glucose-insulin bolus can unmask the Brugada electrocardiographic signature in genetically predisposed individuals. In this report we present a 16-year-old male...

Dendritic ion channelopathy in acquired epilepsy.

Ion channel dysfunction or "channelopathy" is a proven cause of epilepsy in the relatively uncommon genetic epilepsies with Mendelian inheritance. But numerous examples of acquired channelopathy in experimental animal models of epilepsy following brain injury have also been demonstrated. Our understanding of channelopathy has grown due to advances in electrophysiology techniques that have allow...

Long QT syndrome - a genetic cardiac channelopathy.

INTRODUCTION Long QT-syndrome (LQTS) is a genetic cardiac channelopathy characterised by a prolonged QT interval on a surface electrocardiogram (ECG), syncope, T-wave abnormalities, ventricular tachycardia of the torsades de pointes (TdPVT) type (Fig. 1) and an increased risk of sudden death [1]. LQTS has variable clinical presentation and is genetically characterised by incomplete penetrance, ...

Factors contributing to resistant hypertension. Cardiac considerations.

Medical treatment of hypertension has beneficial effects in the prevention of complications of the disease and in prolongation of survival. Nevertheless, the control of hypertension may sometimes be difficult. In this respect, the heart itself may interfere with blood pressure control because of increased cardiac output or because of cardiogenic reflexes that could conceivably not only initiate...